Naquotinib mesylate
CAS No. 1448237-05-5
Naquotinib mesylate ( ASP-8273 )
Catalog No. M11914 CAS No. 1448237-05-5
Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
50MG | 735 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameNaquotinib mesylate
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NoteResearch use only, not for human use.
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Brief DescriptionNaquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR.
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DescriptionNaquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)); more potently than that of WT EGFR (IC50= 230 nM); shows activity in mutant EGFR cell line which is resistant to other EGFR TKIs including AZD9291 and CO-1686.Lung Cancer Phase 3 Clinical
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SynonymsASP-8273
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number1448237-05-5
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Formula Weight658.81
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Molecular FormulaC31H46N8O6S
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Purity>98% (HPLC)
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SolubilityDMSO: 12.5 mg/mL
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SMILESCCC1=C(N=C(C(=N1)C(=O)N)NC2=CC=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC5CCN(C5)C(=O)C=C.CS(=O)(=O)O
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Chemical Name2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-, methanesulfonate (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.
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