Cart
sales@molnova.com
Naquotinib mesylate
CAS No. 1448237-05-5
Naquotinib mesylate ( ASP-8273 )
Catalog No. M11914 CAS No. 1448237-05-5
Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 735 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameNaquotinib mesylate
-
NoteResearch use only, not for human use.
-
Brief DescriptionNaquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR.
-
DescriptionNaquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)); more potently than that of WT EGFR (IC50= 230 nM); shows activity in mutant EGFR cell line which is resistant to other EGFR TKIs including AZD9291 and CO-1686.Lung Cancer Phase 3 Clinical
-
SynonymsASP-8273
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR
-
Research AreaCancer
-
IndicationLung Cancer
Chemical Information
-
CAS Number1448237-05-5
-
Formula Weight658.81
-
Molecular FormulaC31H46N8O6S
-
Purity>98% (HPLC)
-
SolubilityDMSO: 12.5 mg/mL
-
SMILESCCC1=C(N=C(C(=N1)C(=O)N)NC2=CC=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC5CCN(C5)C(=O)C=C.CS(=O)(=O)O
-
Chemical Name2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-, methanesulfonate (1:1)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.
molnova catalog
related products
-
Monastrol（b）
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
-
Anlotinib
Anlotinib (AL-3818) is a novel multi-target tyrosine kinase that primarily inhibit VEGFR2/3, FGFR1-4, PDGFR α/β, c-Kit, and Ret.
-
HKI-357
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM). HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
