Naquotinib mesylate

CAS No. 1448237-05-5

Naquotinib mesylate ( ASP-8273 )

Catalog No. M11914 CAS No. 1448237-05-5

Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Naquotinib mesylate
  • Note
    Research use only, not for human use.
  • Brief Description
    Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR.
  • Description
    Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)); more potently than that of WT EGFR (IC50= 230 nM); shows activity in mutant EGFR cell line which is resistant to other EGFR TKIs including AZD9291 and CO-1686.Lung Cancer Phase 3 Clinical
  • Synonyms
    ASP-8273
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    Cancer
  • Indication
    Lung Cancer

Chemical Information

  • CAS Number
    1448237-05-5
  • Formula Weight
    658.81
  • Molecular Formula
    C31H46N8O6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 12.5 mg/mL
  • SMILES
    CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC5CCN(C5)C(=O)C=C.CS(=O)(=O)O
  • Chemical Name
    2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-, methanesulfonate (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.
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